Email this article Effect of N-[Imino(1-Piperidinyl)Methyl]Guanidine on Free-Radical Processes and Antioxidant-Enzyme Activity in Kidneys of Rats with Experimental Type 2 Diabetes Mellitus
- Authors: Sklyarova E.I.1, Popova T.N.1, Shul’gin K.K.1, Spitsina V.V.1, Kryl’skii D.V.2, Semenikhina A.V.1
-
Affiliations:
- Voronezh State University
- Center for High Technology, Scientific Research Institute of Applied Acoustics
- Issue: Vol 52, No 3 (2018)
- Pages: 191-194
- Section: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/245071
- DOI: https://doi.org/10.1007/s11094-018-1788-3
- ID: 245071
Cite item
Open Access
Access granted
Subscription Access
Abstract
The effect of the synthetic biguanide derivative N-[imino(1-piperidinyl)methyl]guanidine on free-radical processes, diene conjugate levels, and superoxide-dismutase and catalase activity in kidneys of rats with experimental type 2 diabetes mellitus (DM2) was studied. It was established that administration of this compound to rats with DM2 helped to normalize the studied parameters, which may have been due to its positive regulating effect on free-radical homeostasis.
About the authors
E. I. Sklyarova
Voronezh State University
Author for correspondence.
Email: katttilda@mail.ru
Russian Federation, 1 Universitetskaya Sq., Voronezh, 394018
T. N. Popova
Voronezh State University
Email: katttilda@mail.ru
Russian Federation, 1 Universitetskaya Sq., Voronezh, 394018
K. K. Shul’gin
Voronezh State University
Email: katttilda@mail.ru
Russian Federation, 1 Universitetskaya Sq., Voronezh, 394018
V. V. Spitsina
Voronezh State University
Email: katttilda@mail.ru
Russian Federation, 1 Universitetskaya Sq., Voronezh, 394018
D. V. Kryl’skii
Center for High Technology, Scientific Research Institute of Applied Acoustics
Email: katttilda@mail.ru
Russian Federation, 7A 9th of May St., Dubna-1, Moscow Oblast, 141981
A. V. Semenikhina
Voronezh State University
Email: katttilda@mail.ru
Russian Federation, 1 Universitetskaya Sq., Voronezh, 394018
