Hydrogel Nanoparticles of Chitosan—Folic-Acid Conjugate with Imatinib Methanesulfonate

Abstract

Hydrogel particles containing up to 49 mass% imatinib methanesulfonate (mesylate) (IM) were prepared from the chitosan—folic-acid conjugate. The release kinetics of IM from the particles in solutions simulating physiological body media were studied. It was established that the release kinetics of IM from the chitosan—folic-acid conjugate particles obeyed the Korsmeyer—Peppas model and a reciprocal power function of time. It was shown that the release rate of IM from the hydrogel particles could be controlled by varying the folic-acid content in the conjugate.