Email this article Hydrogel Nanoparticles of Chitosan—Folic-Acid Conjugate with Imatinib Methanesulfonate
- Authors: Lozovskaya M.É.1, Kulikovskaya V.I.1, Ignatovich Z.V.1, Koroleva E.V.1, Agabekov V.E.1
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Affiliations:
- Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
- Issue: Vol 52, No 2 (2018)
- Pages: 127-132
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245025
- DOI: https://doi.org/10.1007/s11094-018-1777-6
- ID: 245025
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Abstract
Hydrogel particles containing up to 49 mass% imatinib methanesulfonate (mesylate) (IM) were prepared from the chitosan—folic-acid conjugate. The release kinetics of IM from the particles in solutions simulating physiological body media were studied. It was established that the release kinetics of IM from the chitosan—folic-acid conjugate particles obeyed the Korsmeyer—Peppas model and a reciprocal power function of time. It was shown that the release rate of IM from the hydrogel particles could be controlled by varying the folic-acid content in the conjugate.
About the authors
M. É. Lozovskaya
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: chem@folium.ru
Belarus, Minsk, 220141
V. I. Kulikovskaya
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: chem@folium.ru
Belarus, Minsk, 220141
Zh. V. Ignatovich
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: chem@folium.ru
Belarus, Minsk, 220141
E. V. Koroleva
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: chem@folium.ru
Belarus, Minsk, 220141
V. E. Agabekov
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: chem@folium.ru
Belarus, Minsk, 220141
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