Email this article Antitumor Potential of Substances from the Fungus Ganoderma lucidum
- Authors: Petrova E.S.1,2, Rudina M.I.1, Shvarts Y.S.3
-
Affiliations:
- Science Research Institute of Therapy and Prophylactic Medicine, Russian Academy of Sciences
- Institute of Solid Body Chemistry and Mechanistic Chemistry
- Novosibirsk Science Research Institute of Tuberculosis, Russian Ministry of Health
- Issue: Vol 52, No 1 (2018)
- Pages: 57-62
- Section: Medicinal Herbs
- URL: https://journals.rcsi.science/0091-150X/article/view/244987
- DOI: https://doi.org/10.1007/s11094-018-1765-x
- ID: 244987
Cite item
Open Access
Access granted
Subscription Access
Abstract
We present here a review of published data mostly from the last 10 years on the antitumor activity of substances from the fungus Ganoderma lucidum. Its main biologically active components are described, particularly triterpenes, polysaccharides, glycoproteins, and proteoglycans. The mechanisms of the antitumor actions of these compounds in vitro and in vivo are discussed, these including blockade of the cell cycle, induction of apoptosis, decreases in the metastatic potential, suppression of angiogenesis, and immunomodulatory activity. The potential of using substances from G. lucidum for the treatment of oncological patients is assessed.
About the authors
E. S. Petrova
Science Research Institute of Therapy and Prophylactic Medicine, Russian Academy of Sciences; Institute of Solid Body Chemistry and Mechanistic Chemistry
Email: chem@folium.ru
Russian Federation, 175/1 B. Bogatkov Street, Novosibirsk, 630089; 18 Kutateladze Street, Novosibirsk, 630128
M. I. Rudina
Science Research Institute of Therapy and Prophylactic Medicine, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 175/1 B. Bogatkov Street, Novosibirsk, 630089
Ya. Sh. Shvarts
Novosibirsk Science Research Institute of Tuberculosis, Russian Ministry of Health
Email: chem@folium.ru
Russian Federation, 81a Okhotskaya Street, Novosibirsk, 630040
