Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring
- Authors: Khaliullin F.A.1, Shabalina Y.V.1, Samorodov A.V.1, Kamilov F.K.1, Timirkhanova G.A.1, Murataev D.Z.1
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Affiliations:
- Bashkir State Medical University
- Issue: Vol 52, No 1 (2018)
- Pages: 52-56
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244985
- DOI: https://doi.org/10.1007/s11094-018-1764-y
- ID: 244985
Cite item
Abstract
Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 – 93%. Interaction of these acids with bases (sodium hydroxide, morpholine, hexamethyleneimine) produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acid salts containing a thietane ring, with yields of 44 – 96%. The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity.
Keywords
About the authors
F. A. Khaliullin
Bashkir State Medical University
Email: chem@folium.ru
Russian Federation, Ufa
Yu. V. Shabalina
Bashkir State Medical University
Email: chem@folium.ru
Russian Federation, Ufa
A. V. Samorodov
Bashkir State Medical University
Email: chem@folium.ru
Russian Federation, Ufa
F. Kh. Kamilov
Bashkir State Medical University
Email: chem@folium.ru
Russian Federation, Ufa
G. A. Timirkhanova
Bashkir State Medical University
Email: chem@folium.ru
Russian Federation, Ufa
D. Z. Murataev
Bashkir State Medical University
Email: chem@folium.ru
Russian Federation, Ufa