Effects of 3-Hydroxypyridine and Succinic Acid Derivatives on Monoamine Oxidase Activity In Vitro
- Authors: Volchegorskii I.A.1, Sinitskii A.I.1, Miroshnichenko I.Y.1, Rassokhina L.M.1
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Affiliations:
- Southern Urals State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 52, No 1 (2018)
- Pages: 26-29
- Section: Molecular Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/244975
- DOI: https://doi.org/10.1007/s11094-018-1760-2
- ID: 244975
Cite item
Abstract
The effects of original Russian 3-hydroxypyridine and succinic acid derivatives (emoxypine, Reamberin, and Mexidol) on monoamine oxidase (MAO-A and MAO-B) activity in rat liver were studied in vitro. The study drugs used in vitro at concentrations in the pharmacokinetic range (10 9 to 10 6 M), were found to have MAO-modulating actions, the directions depending on their chemical structural properties. The isolated 3-hydroxypyridine derivative emoxypine decreased MAO-A activity by 34 – 44% and MAO-B activity by 9 – 10% (p < 0.05 in both cases). The succinic acid derivative Reamberin increased MAO-A activity by 2-3% and MAO-B activity by 14% (p < 0.05 in both cases). Mexidol, which is a derivative of both 3-hydroxypyridine and succinic acid, decreased MAO-A activity by 13% and MAO-B activity by 4% (p < 0.05 in both cases). The 2-ethyl-3-methyl-3-hydroxypyridinium cation and the succinate anion were antagonists in terms of their MAO-modulating actions. Combining these antagonist ions into the structure of Mexidol led to complete loss of the MAO-stimulating effect of the succinate part and a significant reduction in the MAO-inhibiting action of the 3-hydroxypyridine component.
About the authors
I. A. Volchegorskii
Southern Urals State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: volcheg@yandex.ru
Russian Federation, 64 Vorovskii Street, Chelyabinsk, 454092
A. I. Sinitskii
Southern Urals State Medical University, Ministry of Health of the Russian Federation
Email: volcheg@yandex.ru
Russian Federation, 64 Vorovskii Street, Chelyabinsk, 454092
I. Yu. Miroshnichenko
Southern Urals State Medical University, Ministry of Health of the Russian Federation
Email: volcheg@yandex.ru
Russian Federation, 64 Vorovskii Street, Chelyabinsk, 454092
L. M. Rassokhina
Southern Urals State Medical University, Ministry of Health of the Russian Federation
Email: volcheg@yandex.ru
Russian Federation, 64 Vorovskii Street, Chelyabinsk, 454092