Encapsulation and Controlled Release of Vitamin B2 Using Peracetyl-β-Cyclodextrin Polymer-Based Electrospun Nanofiber Scaffold

Abstract

Hydrophobic β-cyclodextrin polymer nanofibers were obtained by the electrospinning of peracetyl-β-cyclodextrin polymer (AcβCDP) from acetone : DMF (3 : 2 v/v) solution. The morphology of AcβCDP nanofibers was studied by scanning electron microscopy. The proposed novel hydrophobic β-CD polymer was synthesized through reaction of water-soluble β-CD polymer crosslinked with epichlorohydrin (β-CD-ECH polymer) and acetic anhydride in the presence of pyridine. The peracylation of β-CD-ECH polymer is verified by FT-IR and solubility data. The final part of this study is focused on incorporating vitamin B₂ (VB₂) into the AcβCDP nanofiber. In vitro release of VB₂ from AcβCDP/VB₂ nanofiber in model physiological media was investigated; the results exhibited initial burst and then slow drug release. The release of VB₂ from AcβCDP/VB₂ nanofiber is slower than from AcβCDP/VB₂.