Мақаланы E-mail арқылы жіберу Determination of Bacterial Endotoxins in Drugs: False-Negative Results
- Авторлар: Shapovalova O.V.1, Neugodova N.P.1, Sapozhnikova G.A.1, Simutenko L.V.1, Agashirinova A.A.1
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Мекемелер:
- Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
- Шығарылым: Том 51, № 12 (2018)
- Беттер: 1119-1122
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244937
- DOI: https://doi.org/10.1007/s11094-018-1751-3
- ID: 244937
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Аннотация
One of the possible causes of false-negatives in bacterial endotoxin determinations, endotoxin aggregation and adsorption, was examined in a model experiment (positive control). A solution for eliminating the interfering actor using kinetic methods and a dispersing solvent was proposed based with the drug caspofungin as an example.
Авторлар туралы
O. Shapovalova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051
N. Neugodova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051
G. Sapozhnikova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051
L. Simutenko
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051
A. Agashirinova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051
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