Email this article Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring
- Authors: Rodina T.A.1,2, Mel’nikov E.S.2,3, Dmitriev A.I.2,3, Belkov S.A.1,2,3, Sokolov A.V.1,3, Arkhipov V.V.1,3, Prokof’ev A.B.1,2,3
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Affiliations:
- Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
- I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
- 3I. M. Sechenov First Moscow State Medical University
- Issue: Vol 51, No 12 (2018)
- Pages: 1111-1118
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244934
- DOI: https://doi.org/10.1007/s11094-018-1750-4
- ID: 244934
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Abstract
A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime.
About the authors
T. A. Rodina
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240
E. S. Mel’nikov
I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; 3I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
A. I. Dmitriev
I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; 3I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
S. A. Belkov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; 3I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
A. V. Sokolov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; 3I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
V. V. Arkhipov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; 3I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
A. B. Prokof’ev
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; 3I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
