Synthesis and Biological Activity of 2-Mercapto-7,10-Dimethyl-3H-Spiro[Benzo[H]Quinazoline-5,1′-Cyclopentane]-4(6H)-One from Ethyl 4′-Amino-5′,8′-Dimethyl-1′H-Spiro[Cyclopentane-1,2′-Naphthalene]-3′-Carboxylate
- Authors: Grigoryan N.P.1, Markosyan A.I.1, Grigoryan A.S.1, Stepanyan G.A.1, Sukasyan R.S.1, Paronikyan R.G.1
-
Affiliations:
- A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
- Issue: Vol 51, No 12 (2018)
- Pages: 1057-1062
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244912
- DOI: https://doi.org/10.1007/s11094-018-1740-6
- ID: 244912
Cite item
Abstract
A synthetic method for 7,10-dimethyl-2-thioxo-2,3-dihydro-1H-spiro[benzo[h]quinazoline-5,1′-cyclopentane]- 4(6H)-one from ethyl 4′-amino-5′,8′-dimethyl-1′-H-spiro[cyclopentane-1,2′-naphthalene]-3′-carboxylate was developed. Reaction of the spirobenzo[h]quinazoline with various alkyl(benzyl) halides synthesized a novel series of spirobenzo[h]quinazolines containing methyl substituents on the benzene ring. The antidepressant, anticonvulsant, and antibacterial activities of the synthesized spirobenzo[h]quinazolines were investigated.
About the authors
N. P. Grigoryan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Author for correspondence.
Email: nver-55@mail.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014
A. I. Markosyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: nver-55@mail.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014
A. S. Grigoryan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: nver-55@mail.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014
G. A. Stepanyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: nver-55@mail.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014
R. S. Sukasyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: nver-55@mail.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014
R. G. Paronikyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: nver-55@mail.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014