Email this article Experimental Antioxidant Activity of a β-Cyclodextrin – Histochrome Complex
- Authors: Bikbov M.M.1, Nikitin N.A.1, Surkova V.K.1, Farkhutdinov R.R.2, Khalilov L.M.3, Tulyabaev A.R.3, Nikitina A.F.1, Fedoreev S.A.4, Mishchenko N.P.4
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Affiliations:
- Ufa Eye Research Institute, Academy of Sciences of the Republic of Bashkortostan
- Bashkir State Medical University, MH RF
- Institute of Petrochemistry and Catalysis, Ufa Scientific Center, Russian Academy of Sciences
- G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
- Issue: Vol 51, No 11 (2018)
- Pages: 980-984
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244880
- DOI: https://doi.org/10.1007/s11094-018-1727-3
- ID: 244880
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Abstract
A2:1 β-cyclodextrin – histochrome complex was synthesized based on a comparison with experimental studies of histochrome and showed antioxidant activity prolonged to 16 d as compared with 6 d for histochrome in tests of the duration of the in vitro antioxidant effect. PMR measurements proved that a β-cyclodextrin – histochrome complex formed. Computer modeling of the β-cyclodextrin–histochrome complex showed that the head-to-tail complex corresponded to the energy minimum.
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About the authors
M. M. Bikbov
Ufa Eye Research Institute, Academy of Sciences of the Republic of Bashkortostan
Email: chem@folium.ru
Russian Federation, Ufa, Bashkortostan, 450008
N. A. Nikitin
Ufa Eye Research Institute, Academy of Sciences of the Republic of Bashkortostan
Email: chem@folium.ru
Russian Federation, Ufa, Bashkortostan, 450008
V. K. Surkova
Ufa Eye Research Institute, Academy of Sciences of the Republic of Bashkortostan
Email: chem@folium.ru
Russian Federation, Ufa, Bashkortostan, 450008
R. R. Farkhutdinov
Bashkir State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, Ufa, Bashkortostan, 450008
L. M. Khalilov
Institute of Petrochemistry and Catalysis, Ufa Scientific Center, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, Ufa, Bashkortostan, 450054
A. R. Tulyabaev
Institute of Petrochemistry and Catalysis, Ufa Scientific Center, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, Ufa, Bashkortostan, 450054
A. F. Nikitina
Ufa Eye Research Institute, Academy of Sciences of the Republic of Bashkortostan
Email: chem@folium.ru
Russian Federation, Ufa, Bashkortostan, 450008
S. A. Fedoreev
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, Vladivostok, 690922
N. P. Mishchenko
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, Vladivostok, 690922
