Preparation and Properties of Protamine/Pectin-Ag Biopolymer Microcapsules Containing a 2-Arylaminopyrimidine Derivative
- Authors: Gilevskaya K.S.1, Ignatovich Z.V.1, Golubeva M.B.2, Koroleva E.V.1, Agabekov V.E.1
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Affiliations:
- Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
- Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
- Issue: Vol 51, No 10 (2018)
- Pages: 922-927
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244859
- DOI: https://doi.org/10.1007/s11094-018-1717-5
- ID: 244859
Cite item
Abstract
A synthetic 2-arylaminopyrimidine derivative (analog of imatinib mesylate) was incorporated into multilayer polyelectrolyte microcapsules prepared by alternating adsorption of protamine sulfate and pectin-Ag nanocomposite. The encapsulation effectiveness (EE) from an aqueous solution of the compound (4 mg/mL) was ~70% and reached 28 mass%. The release kinetics from the microcapsules depended significantly on the solution pH and ionic strength. Release of the imatinib analog was prolonged most in alkaline solutions. In vitro experiments on hemoblast suspension cultures showed that microencapsulation of the 2-arylaminopyrimidine derivative changed its antitumor activity and lowered the IC50 value by 1.4 – 2.2 times.
About the authors
K. S. Gilevskaya
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Author for correspondence.
Email: k_hilevskay@mail.ru
Belarus, Minsk, 220141
Zh. V. Ignatovich
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: k_hilevskay@mail.ru
Belarus, Minsk, 220141
M. B. Golubeva
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Email: k_hilevskay@mail.ru
Belarus, Minsk, 220141
E. V. Koroleva
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: k_hilevskay@mail.ru
Belarus, Minsk, 220141
V. E. Agabekov
Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus
Email: k_hilevskay@mail.ru
Belarus, Minsk, 220141