Email this article Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis
- Authors: Gautham Shenoy G.1, Kar S.S.1, Shenoy V.2, Bairy I.3, Ganesh Kumar T.N.1
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Affiliations:
- Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University
- Department of Microbiology, Kasturba Medical College, Manipal University
- Department of Microbiology, Melaka-Manipal Medical College, Manipal University
- Issue: Vol 51, No 10 (2018)
- Pages: 907-917
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244853
- DOI: https://doi.org/10.1007/s11094-018-1714-8
- ID: 244853
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Abstract
Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.
About the authors
G. Gautham Shenoy
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University
Email: ganeshtnv@gmail.com
India, Manipal, 576104
Sidhartha Sankar Kar
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University
Email: ganeshtnv@gmail.com
India, Manipal, 576104
Vishnu Shenoy
Department of Microbiology, Kasturba Medical College, Manipal University
Email: ganeshtnv@gmail.com
India, Manipal, 576104
Indira Bairy
Department of Microbiology, Melaka-Manipal Medical College, Manipal University
Email: ganeshtnv@gmail.com
India, Manipal, 576104
T. N. V. Ganesh Kumar
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University
Author for correspondence.
Email: ganeshtnv@gmail.com
India, Manipal, 576104
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