Validation of a Method of Measuring Mean Molecular Weight of Dextrans by Diffusion-Ordered Spectroscopy
- Authors: Moiseev S.V.1, Kuz’mina N.E.1, Krylov V.I.1, Yashkir V.A.1, Merkulov V.A.1
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Affiliations:
- Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
- Issue: Vol 51, No 9 (2017)
- Pages: 829-832
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244820
- DOI: https://doi.org/10.1007/s11094-017-1701-5
- ID: 244820
Cite item
Abstract
Amethod for measuring the mean molecular weight of dextrans by diffusion-ordered NMR spectroscopy was developed and validated. This method allows measurements of dextran self-diffusion coefficients to determine their mean molecular weight. The linearity, correctness, similarity, intralaboratory precision, and specificity of the method were evaluated. “Added/found” ratios for different dextrans were used to determine the standard deviations, coefficients of variation, significance intervals, systematic errors, Fisher’s F test, and Student’s t test for measurements of mean molecular weight. These statistical characteristics satisfied the criteria for validation parameters in the Russian and foreign normative documentation.
About the authors
S. V. Moiseev
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Author for correspondence.
Email: MoiseevSV@expmed.ru
Russian Federation, Building 2, 8 Petrovskii Boulevard, Moscow, 127051
N. E. Kuz’mina
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: MoiseevSV@expmed.ru
Russian Federation, Building 2, 8 Petrovskii Boulevard, Moscow, 127051
V. I. Krylov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: MoiseevSV@expmed.ru
Russian Federation, Building 2, 8 Petrovskii Boulevard, Moscow, 127051
V. A. Yashkir
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: MoiseevSV@expmed.ru
Russian Federation, Building 2, 8 Petrovskii Boulevard, Moscow, 127051
V. A. Merkulov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: MoiseevSV@expmed.ru
Russian Federation, Building 2, 8 Petrovskii Boulevard, Moscow, 127051