Synthesis and Antitumor Activity of 2-N-,3-S-Substituted 5-(4-Benzyloxyphenyl)-1,2,4-Triazoles
- Authors: Kaldrikyan M.A.1, Melik-Ohanjanyan R.G.1, Arsenyan F.H.1
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Affiliations:
- A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
- Issue: Vol 51, No 9 (2017)
- Pages: 760-763
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244791
- DOI: https://doi.org/10.1007/s11094-017-1688-y
- ID: 244791
Cite item
Abstract
Cyclization of substituted thiosemicarbazides in alkaline medium was used to synthesize the corresponding 3-thio-4-benzyl(cyclohexyl, allyl)-5-(4-benzyloxyphenyl)-1,2,4-triazoles. These compounds were 3-S-alkylated with ethylene chlorohydrin, chloroacetamide, 3-bromo-4-methoxybenzyl chloride, and chloroacetic, 2-bromopropionic, and 2-bromocaproic acids. Aminomethylation and oxymethylation reactions were studied. 2-N-Aminomethylene and 2-N-oxymethylenetriazoline-3-thiones were prepared. The antitumor activity of the compounds synthesized here were studied.
About the authors
M. A. Kaldrikyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: chem@folium.ru
Armenia, 26 Azatutyan Prospekt, Erevan, 0014
R. G. Melik-Ohanjanyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: chem@folium.ru
Armenia, 26 Azatutyan Prospekt, Erevan, 0014
F. H. Arsenyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: chem@folium.ru
Armenia, 26 Azatutyan Prospekt, Erevan, 0014