Colorimetric and Indirect X-Ray Fluorescence Determination of Drug Substances Using Chemically Modified Polyurethane-Foam Absorbents

Abstract

Acombined chemical and instrumental approach is proposed for improving the metrological characteristics of drug determinations in pharmaceutical preparations covering the classes antibiotics, antioxidants, antiseptics, and anesthetics. Simple and accessible colorimetric and indirect x-ray fluorescence methods for determining 8-hydroxyquinoline, novocaine, quercetin, and tetracycline in pharmaceuticals using chemically modified polyurethane foam absorbents were developed based on this approach. The developed approach could be used to determine active ingredients for preliminary quality control of drugs.