Email this article Optimization of Drug Administration Dosage Regimen Considering Chronorhythms and Desynchronosis of Gastrointestinal-Tract Organs
- Authors: Bunyatyan N.D.1,2, Drogovoz S.M.3, Kononenko A.V.3, Olefir Y.V.1,2, Prokof’ev A.B.1,2
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Affiliations:
- I. M. Sechenov First Moscow State Medical University
- Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
- National University of Pharmacy
- Issue: Vol 51, No 8 (2017)
- Pages: 695-697
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244759
- DOI: https://doi.org/10.1007/s11094-017-1676-2
- ID: 244759
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Abstract
Medicinal effects on gastrointestinal-tract (GIT) organs under normal and pathological conditions are reviewed and analyzed. It is shown that rhythmic processes of digestive organs interact closely with the hierarchical structure of partial in vivo rhythms. This creates the prerequisites for prescribing medicines for GIT disorders considering individual in vivo chronorhythms and drug pharmacokinetic profiles.
About the authors
N. D. Bunyatyan
I. M. Sechenov First Moscow State Medical University; Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051
S. M. Drogovoz
National University of Pharmacy
Email: chem@folium.ru
Ukraine, Kharkiv, 61000
A. V. Kononenko
National University of Pharmacy
Email: chem@folium.ru
Ukraine, Kharkiv, 61000
Yu. V. Olefir
I. M. Sechenov First Moscow State Medical University; Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051
A. B. Prokof’ev
I. M. Sechenov First Moscow State Medical University; Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051
