Synthesis, in vitro Antibacterial and in vivo Anti-Inflammatory Activity of Some New Pyridines
- Authors: Ghattas A.A.1, Khodairy A.1, Moustafa H.M.1, Hussein B.R.1, Farghaly M.M.2, Aboelez M.O.3
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Affiliations:
- Chemistry Department, Faculty of Science, Sohag University
- Division of Microbiology, Botany Department, Faculty of Science, Sohag University
- Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Sohag University
- Issue: Vol 51, No 8 (2017)
- Pages: 652-660
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244746
- DOI: https://doi.org/10.1007/s11094-017-1670-8
- ID: 244746
Cite item
Abstract
Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group, 1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied.
About the authors
Abd-El-Badih A. G. Ghattas
Chemistry Department, Faculty of Science, Sohag University
Email: bahgat.ramadan@yahoo.com
Egypt, Sohag, 82524
Ahmed Khodairy
Chemistry Department, Faculty of Science, Sohag University
Email: bahgat.ramadan@yahoo.com
Egypt, Sohag, 82524
Hassan M. Moustafa
Chemistry Department, Faculty of Science, Sohag University
Author for correspondence.
Email: bahgat.ramadan@yahoo.com
Egypt, Sohag, 82524
Bahgat R. M. Hussein
Chemistry Department, Faculty of Science, Sohag University
Email: bahgat.ramadan@yahoo.com
Egypt, Sohag, 82524
Marwa M. Farghaly
Division of Microbiology, Botany Department, Faculty of Science, Sohag University
Email: bahgat.ramadan@yahoo.com
Egypt, Sohag
Moustafa O. Aboelez
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Sohag University
Email: bahgat.ramadan@yahoo.com
Egypt, Sohag