Search for Anti-Inflammatory Agents in the Tetrahydropyrido[2,1- B  ][1,3,5]-Thiadiazine Series

E. Yu. Bibik; O. G. Yaroshevskaya; A. V. Devdera; A. V. Demenko; V. V. Zakharov; K. A. Frolov; V. V. Dotsenko; S. G. Krivokolysko

doi:10.1007/s11094-017-1669-1

Search for Anti-Inflammatory Agents in the Tetrahydropyrido[2,1-B ][1,3,5]-Thiadiazine Series

Authors: Bibik E.Y.¹, Yaroshevskaya O.G.¹, Devdera A.V.¹, Demenko A.V.¹, Zakharov V.V.¹, Frolov K.A.¹^,2, Dotsenko V.V.²^,3, Krivokolysko S.G.¹^,2
Affiliations:
1. Lugansk State Medical University
2. ChemEx Laboratory, Vladimir Dal’ Lugansk State University
3. Kuban State University
Issue: Vol 51, No 8 (2017)
Pages: 648-651
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244744
DOI: https://doi.org/10.1007/s11094-017-1669-1
ID: 244744

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Abstract

Tetrahydropyrido[2,1-b ][1,3,5]thiadiazine derivatives were investigated for anti-inflammatory activity as compared with that of diclofenac sodium using the formalin-induced paw edema model in albino rats. Compounds with anti-inflammatory activity 1.5 – 3.5 times more potent than that of diclofenac sodium were discovered.