Synthesis and Antimicrobial Activity of 4-Hydroxy-2-[5-Nitrofuran(Thien)-2-Yl]-6h-1,3-Oxazin-6-Ones
- Authors: Chernov N.M.1, Koshevenko A.S.1, Yakovlev I.P.1, Anan’eva E.P.1, Ksenofontova G.V.1, Shchegolev A.E.1
-
Affiliations:
- St. Petersburg State Chemical Pharmaceutical Academy
- Issue: Vol 51, No 8 (2017)
- Pages: 644-647
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244743
- DOI: https://doi.org/10.1007/s11094-017-1668-2
- ID: 244743
Cite item
Abstract
A series of new 4-hydroxy-6H-oxazin-6-ones containing 2-(5-nitrofuranyl) and 2-(5-nitrothienyl) moieties were obtained. New nitrofuran and thiophene derivatives were synthesized by reacting these oxazines with mono- (EtOH) and dinucleophiles (phenylhydrazine). It was established that the synthesized compounds possessed pronounced bactericidal activity against Staphylococcus aureus and, in some cases, Escherichia coli strains.
About the authors
N. M. Chernov
St. Petersburg State Chemical Pharmaceutical Academy
Author for correspondence.
Email: nikita.chernov@pharminnotech.com
Russian Federation, 14/A Ul. Prof. Popova, St. Petersburg, 197376
A. S. Koshevenko
St. Petersburg State Chemical Pharmaceutical Academy
Email: nikita.chernov@pharminnotech.com
Russian Federation, 14/A Ul. Prof. Popova, St. Petersburg, 197376
I. P. Yakovlev
St. Petersburg State Chemical Pharmaceutical Academy
Email: nikita.chernov@pharminnotech.com
Russian Federation, 14/A Ul. Prof. Popova, St. Petersburg, 197376
E. P. Anan’eva
St. Petersburg State Chemical Pharmaceutical Academy
Email: nikita.chernov@pharminnotech.com
Russian Federation, 14/A Ul. Prof. Popova, St. Petersburg, 197376
G. V. Ksenofontova
St. Petersburg State Chemical Pharmaceutical Academy
Email: nikita.chernov@pharminnotech.com
Russian Federation, 14/A Ul. Prof. Popova, St. Petersburg, 197376
A. E. Shchegolev
St. Petersburg State Chemical Pharmaceutical Academy
Email: nikita.chernov@pharminnotech.com
Russian Federation, 14/A Ul. Prof. Popova, St. Petersburg, 197376