Synthesis and Antimicrobial Activity of 4-Hydroxy-2-[5-Nitrofuran(Thien)-2-Yl]-6h-1,3-Oxazin-6-Ones

N. M. Chernov; A. S. Koshevenko; I. P. Yakovlev; E. P. Anan’eva; G. V. Ksenofontova; A. E. Shchegolev

doi:10.1007/s11094-017-1668-2

Synthesis and Antimicrobial Activity of 4-Hydroxy-2-[5-Nitrofuran(Thien)-2-Yl]-6h-1,3-Oxazin-6-Ones

Authors: Chernov N.M.¹, Koshevenko A.S.¹, Yakovlev I.P.¹, Anan’eva E.P.¹, Ksenofontova G.V.¹, Shchegolev A.E.¹
Affiliations:
1. St. Petersburg State Chemical Pharmaceutical Academy
Issue: Vol 51, No 8 (2017)
Pages: 644-647
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244743
DOI: https://doi.org/10.1007/s11094-017-1668-2
ID: 244743

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Abstract

A series of new 4-hydroxy-6H-oxazin-6-ones containing 2-(5-nitrofuranyl) and 2-(5-nitrothienyl) moieties were obtained. New nitrofuran and thiophene derivatives were synthesized by reacting these oxazines with mono- (EtOH) and dinucleophiles (phenylhydrazine). It was established that the synthesized compounds possessed pronounced bactericidal activity against Staphylococcus aureus and, in some cases, Escherichia coli strains.