Email this article Synthesis and Anti-Arrhythmic Activity of the Chloride and Salicylate Salts of Morpholinoacetic Acid Ortho-Toluidide
- Authors: Gashkova O.V.1, Rudakova I.P.1, Syropyatov B.Y.1
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Affiliations:
- Perm State Pharmaceutical Academy, Ministry of Health of Russia
- Issue: Vol 51, No 8 (2017)
- Pages: 641-643
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244741
- DOI: https://doi.org/10.1007/s11094-017-1667-3
- ID: 244741
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Abstract
Acylation of ortho-toluidine hydrochloride by chloroacetylchloride followed by amination by morpholine in the presence of an excess of Et3N produced morpholinoacetic acid ortho-toluidide and its salicylate salt. The acute toxicity and anti-arrhythmic and antifibrillatory activities of these compounds were studied. The biological activities indicated that these compounds were promising for further studies and evaluation of their potential for implementation into medical practice.
About the authors
O. V. Gashkova
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: rudakova.i@list.ru
Russian Federation, 46 Krupskoi St., Perm, 614070
I. P. Rudakova
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Author for correspondence.
Email: rudakova.i@list.ru
Russian Federation, 46 Krupskoi St., Perm, 614070
B. Ya. Syropyatov
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: rudakova.i@list.ru
Russian Federation, 46 Krupskoi St., Perm, 614070
