Ce3+ Doped Clindamycin Nanoparticles Loaded in Gelatin Media: Study of Photoluminescence Properties and Antibacterial Effect

Abstract

In this work, Ce³⁺doped clindamycin nanoparticles (Ce³⁺/CLA-NP) loaded in gelatin media were prepared by sol-gel technique and characterized by x-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and photoluminescence (PL) spectra. The PL spectra of Ce³⁺/CLA-NP show two UV bands, at 325 and 355 nm, which are not detected from undoped CLA-NP. The morphology of the nanocomposite and the size of nanoparticles were estimated by scanning electron microscopy (SEM). The average particle size in Ce³⁺/CLA-NP was about 50 – 120 nm. The drug release profile was determined by UV–Vis spectroscopy. Finally, in vitro antibacterial properties of Ce³⁺/CLA-NP were evaluated against Staphylococcus aureus.