Dehydration of 9a-Hydroxyandrost-4-ene-3,17-Dione in Organic Solvents
- Authors: Savinova T.S.1, Kazantsev A.V.2, Huy L.D.2, Lukashev N.V.1
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Affiliations:
- M. V. Lomonosov Moscow State University, Faculty of Chemistry
- VietNam Academy of Science and Technology, Institute of Chemistry
- Issue: Vol 51, No 7 (2017)
- Pages: 612-615
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244730
- DOI: https://doi.org/10.1007/s11094-017-1662-8
- ID: 244730
Cite item
Abstract
An effective method of dehydrating 9_-hydroxyandrost-4-ene-3,17-dione by mineral acids in organic solvents, producing essentially quantitative formation of androsta-4,9(11)-diene-3,17-dione is proposed. Quantitative isomerization of the side product androsta-4,8(9)-diene-3,17-dione to target product was shown to be pssible.
About the authors
T. S. Savinova
M. V. Lomonosov Moscow State University, Faculty of Chemistry
Author for correspondence.
Email: savinova@org.chem.msu.ru
Russian Federation, Building 3, 1 Lenin Heights, Moscow, 119991
A. V. Kazantsev
VietNam Academy of Science and Technology, Institute of Chemistry
Email: savinova@org.chem.msu.ru
Viet Nam, 18 Hoàng Quoc Viet, Nghia Ðô, Cau Giay
Luu D. Huy
VietNam Academy of Science and Technology, Institute of Chemistry
Email: savinova@org.chem.msu.ru
Viet Nam, 18 Hoàng Quoc Viet, Nghia Ðô, Cau Giay
N. V. Lukashev
M. V. Lomonosov Moscow State University, Faculty of Chemistry
Email: savinova@org.chem.msu.ru
Russian Federation, Building 3, 1 Lenin Heights, Moscow, 119991