Effects of Extracts of Agrimonia Asiatica and Geranium Collinum on Lipid Peroxidation and the Blood Antioxidant Enzyme Activity in Rats with Alloxan Diabetes

Abstract

The effects of 70% ethanolic extracts of the above-ground parts of Agrimonia asiatica Juz. (D1) and the roots of Geranium collinum Steph. (D2) on lipid peroxidation (LPO) and the plasma and erythrocyte levels of activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GP), and glutathione reductase (GR) were studied in rats with alloxan-induced diabetes. Significant decreases in erythrocyte membrane LPO (by 51-80%) were seen with D1 and D2. Extract D1 induced plasma SOD activity (by factors of 1.6 – 2.6) and erythrocyte CAT (by factors of 1.6-2.3). D2 induced SOD activity (by factors of 1.5 – 1.8), CAT activity (by factors of 1.9 – 2.7), and GR activity (by factors of 1.4 – 1.9) in erythrocytes. Both substrates, D1 and D2, showed statistically significant suppression of plasma GR activity (by 7 – 18%) and countered an alloxan-induced increase in erythrocyte GP activity (by 20 – 60%).