Email this article Modification of the Antitumor Action of Cytostatic Drugs Using a Copolymer of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine
- Authors: Panov A.V.1,2, Kochkina Y.V.1,2, Yartsev E.I.2, Eremin D.V.1,2, Yakovleva T.A.2, Kedik S.A.1,2
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Affiliations:
- Moscow Technology University (MITKhT)
- Institute of Pharmaceutical Technologies
- Issue: Vol 51, No 7 (2017)
- Pages: 523-527
- Section: Molecular Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/244693
- DOI: https://doi.org/10.1007/s11094-017-1647-7
- ID: 244693
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Abstract
Simultaneous administration of a copolymer of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine and cytostatic agents to mice with a variety of implanted tumors was found to increase treatment efficacy, promoting increases in survival time. This effect is of interest for further studies of the possible use of copolymer as an immunomodulator in chemotherapy.
About the authors
A. V. Panov
Moscow Technology University (MITKhT); Institute of Pharmaceutical Technologies
Email: alpqa603@mail.ru
Russian Federation, 86 Vernadskii Prospekt, Moscow, 119571; 21/32 Skolkovskoe Chaussee, Moscow, 121353
Yu. V. Kochkina
Moscow Technology University (MITKhT); Institute of Pharmaceutical Technologies
Author for correspondence.
Email: alpqa603@mail.ru
Russian Federation, 86 Vernadskii Prospekt, Moscow, 119571; 21/32 Skolkovskoe Chaussee, Moscow, 121353
E. I. Yartsev
Institute of Pharmaceutical Technologies
Email: alpqa603@mail.ru
Russian Federation, 21/32 Skolkovskoe Chaussee, Moscow, 121353
D. V. Eremin
Moscow Technology University (MITKhT); Institute of Pharmaceutical Technologies
Email: alpqa603@mail.ru
Russian Federation, 86 Vernadskii Prospekt, Moscow, 119571; 21/32 Skolkovskoe Chaussee, Moscow, 121353
T. A. Yakovleva
Institute of Pharmaceutical Technologies
Email: alpqa603@mail.ru
Russian Federation, 21/32 Skolkovskoe Chaussee, Moscow, 121353
S. A. Kedik
Moscow Technology University (MITKhT); Institute of Pharmaceutical Technologies
Email: alpqa603@mail.ru
Russian Federation, 86 Vernadskii Prospekt, Moscow, 119571; 21/32 Skolkovskoe Chaussee, Moscow, 121353
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