Separation of Camptothecin by Ethanol/K 2 CO 3  Aqueous Two-Phase System Containing Tetramethylguanidine

Jian Zhu; Zhi-Min Jin

doi:10.1007/s11094-017-1640-1

Separation of Camptothecin by Ethanol/K₂CO₃ Aqueous Two-Phase System Containing Tetramethylguanidine

Authors: Zhu J.¹, Jin Z.¹
Affiliations:
1. College of Pharmaceutical Sciences, Zhejiang University of Technology
Issue: Vol 51, No 6 (2017)
Pages: 491-493
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244669
DOI: https://doi.org/10.1007/s11094-017-1640-1
ID: 244669

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Abstract
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Abstract

Insoluble camptothecin was converted into the corresponding hydrosoluble analog, camptothecin carboxylate, by using 1,1,3,3-tetramethylguanidine as hydrolyzing agent. The ethanol/K₂CO₃/H₂O aqueous two-phase system was established to extract the hydrosoluble camptothecin carboxylate. Through two-stage extraction from crude camptothecin of 5.4%, purity, final hydrosoluble camptothecin was obtained with a purity of 98.5% at a total yield of 78.4%.

Keywords

camptothecin, aqueous two phase extraction, 1,1,3,3-tetramethylguanidine, hydrolysis

About the authors

Jian Zhu

College of Pharmaceutical Sciences, Zhejiang University of Technology

Email: zdjin99@sina.com
China, Hangzhou, 310014

Zhi-Min Jin