Microencapsulation of Imatinib Methanesulfonate

Abstract

(Protamine—pectin)₄ and (protamine—pectin)8 microcapsules and those containing also Ag nanoparticles were formed using the polyelectrolyte layer-by-layer (LbL) self-assembly method. The efficiency of imatinib methanesulfonate encapsulation in the microcapsules was 85.0 ± 6.0%. Microcapsules containing up to 50 mass% imatinib methanesulfonate and providing a prolonged release profile of the encapsulated drug were prepared. Encapsulation of imatinib in microcapsules increased its cytostatic activity (IC₅₀ values reduced by 1.2 – 3.5 times) as compared with the free drug on the Molt-4, K-562, and KG-1 cell lines.