Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]Dodec-11-EN-4-YL)Ureas

B. A. Selivanov; A. Y. Tikhonov; E. F. Belanov; N. I. Bormotov; A. S. Kabanov; O. Yu. Mazurkov; O. A. Serova; L. N. Shishkina; A. P. Agafonov; A. N. Sergeev

doi:10.1007/s11094-017-1629-9

Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0^2,6.0^8,10]Dodec-11-EN-4-YL)Ureas

Authors: Selivanov B.A.¹, Tikhonov A.Y.¹, Belanov E.F.², Bormotov N.I.², Kabanov A.S.², Mazurkov O.Y.², Serova O.A.², Shishkina L.N.², Agafonov A.P.², Sergeev A.N.²
Affiliations:
1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)
2. VECTOR State Research Center of Virology and Biotechnology
Issue: Vol 51, No 6 (2017)
Pages: 439-443
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244643
DOI: https://doi.org/10.1007/s11094-017-1629-9
ID: 244643

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Abstract
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Abstract

A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(3-fluorophenyl)urea hydrate, and 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(phenyl)thiourea showed pronounced activity.

Keywords

arylisocyanates, arylisothiocyanates, 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)ureas, smallpox vaccines, antiviral activity, pharmacological activity

About the authors

B. A. Selivanov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

Author for correspondence.
Email: seliboba@nioch.nsc.ru
Russian Federation, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090

A. Y. Tikhonov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

Email: seliboba@nioch.nsc.ru
Russian Federation, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090