Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives

Abstract

The hepatoprotective and choleretic activities of three levopimaric acid derivatives were studied experimentally using a CCl₄-induced acute hepatitis model in rats. It was established that all investigated levopimaric acid derivatives tended to increase bile secretion whereas (5R,9R,13S,18S)-20-isopropyl-5,9-dimethyl-17-{[(4-methylphenyl)sulfonyl]imino}-14-oxopentacyclo[10.6.2.0^{1, 10}.0^{4, 9}.0^{13, 18}]eicosa-15,19-diene-5-carboxylic acid (I) and dimethyl (4bS,8R)-2-isopropyl-3^′-4b,8-trimethyl-2^′,4^′-dioxo-4,4a,4b,5,6,7,8,8a,9,10-decahydro-3H-spiro[3,10a-ethanophenanthrene-11,5^′-[1,3]thiazolidine]-8,12-dicarboxylate (II) reduced transaminase enzyme levels in blood serum.