Enzymatic Stability and Possible Molecular Targets of Synthetic Peptide HFRWPGP
- Authors: V’yunova T.V.1, Shevchenko K.V.1, Andreeva L.A.1, Shevchenko V.P.1, Radilov A.S.2, Dulov S.A.2, Petunov S.G.2, Myasoedov N.F.1
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Affiliations:
- Institute of Molecular Genetics, Russian Academy of Sciences
- Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medico-Biological Agency
- Issue: Vol 51, No 5 (2017)
- Pages: 337-339
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244598
- DOI: https://doi.org/10.1007/s11094-017-1609-0
- ID: 244598
Cite item
Abstract
Molecular aspects of the biological mechanism of action of the synthetic peptide HFRWPGP, including an assessment of the stability to membrane proteolytic enzymes and the determination of several intermolecular interaction parameters of the peptide and rat-brain cytoplasmic membranes. It was hypothesized based on the results that the peptide apparently acts as an allosteric activity modulator for several receptor systems and can after the nature of signal transfer to cells. It was established that heptapeptide HFRWPGP in the presence of cerebellum and hippocampus cytoplasmic membranes was degraded in a manner similar to that of Semax proteolysis (used as a reference peptide) under the same incubation conditions.
About the authors
T. V. V’yunova
Institute of Molecular Genetics, Russian Academy of Sciences
Author for correspondence.
Email: ATRegister@mail.ru
Russian Federation, 2 Kurchatov Sq, Moscow, 123182
K. V. Shevchenko
Institute of Molecular Genetics, Russian Academy of Sciences
Email: ATRegister@mail.ru
Russian Federation, 2 Kurchatov Sq, Moscow, 123182
L. A. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences
Email: ATRegister@mail.ru
Russian Federation, 2 Kurchatov Sq, Moscow, 123182
V. P. Shevchenko
Institute of Molecular Genetics, Russian Academy of Sciences
Email: ATRegister@mail.ru
Russian Federation, 2 Kurchatov Sq, Moscow, 123182
A. S. Radilov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medico-Biological Agency
Email: ATRegister@mail.ru
Russian Federation, Bldg. No. 93, Kapitolovo, Leningrad Oblast, Vsevolozhsk District, 188663
S. A. Dulov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medico-Biological Agency
Email: ATRegister@mail.ru
Russian Federation, Bldg. No. 93, Kapitolovo, Leningrad Oblast, Vsevolozhsk District, 188663
S. G. Petunov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medico-Biological Agency
Email: ATRegister@mail.ru
Russian Federation, Bldg. No. 93, Kapitolovo, Leningrad Oblast, Vsevolozhsk District, 188663
N. F. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: ATRegister@mail.ru
Russian Federation, 2 Kurchatov Sq, Moscow, 123182