Synthesis of New 7-bromo-5-(2’-chlorophenyl)-3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine Derivatives and Their Influence on Appetite in Rats
- Authors: Karaseva T.L.1, Likhota E.B.1, Krivenko Y.R.1, Semibrat’ev S.A.1, Pavlovskii V.I.1
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Affiliations:
- A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine
- Issue: Vol 51, No 4 (2017)
- Pages: 258-261
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244559
- DOI: https://doi.org/10.1007/s11094-017-1594-3
- ID: 244559
Cite item
Abstract
A series of new 7-bromo-5-(2′-chlorophenyl)-3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine derivatives (II-VIII) were synthesized. The series of synthesized compounds included those that had a substantial effect on appetite in rats, exhibiting both orexigenic and anorexigenic effects at low doses (2.07 – 2.21 μM). Compound VI had anorexigenic activity comparable with that of the hormone leptin, which reduces the appetite and food intake. Co-administration of leptin and III, which exhibited a pronounced orexigenic effect, reduced appetite by 73%.
Keywords
About the authors
T. L. Karaseva
A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine
Email: victorpavlovsky@ukr.net
Ukraine, Odessa
E. B. Likhota
A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine
Email: victorpavlovsky@ukr.net
Ukraine, Odessa
Ya. R. Krivenko
A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine
Email: victorpavlovsky@ukr.net
Ukraine, Odessa
S. A. Semibrat’ev
A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine
Email: victorpavlovsky@ukr.net
Ukraine, Odessa
V. I. Pavlovskii
A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine
Author for correspondence.
Email: victorpavlovsky@ukr.net
Ukraine, Odessa