Email this article A Chromatographic Method for Assay of Sodium Caprylate in the Formulation “Albumin, Solution for Infusions”
- Authors: Khlybova E.V.1, Kormshchikova E.S.1, Drobkova A.V.1, Paramonov I.V.1
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Affiliations:
- Kirov Science Research Institute of Hematology and Blood Transfusion, Russian Federal Medical-Biological Agency
- Issue: Vol 51, No 3 (2017)
- Pages: 235-238
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244548
- DOI: https://doi.org/10.1007/s11094-017-1589-0
- ID: 244548
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Abstract
A method for assaying sodium caprylate content using gel filtration HPLC and recording of the refractometric detector signal is described. Validation studies demonstrated the suitability of the method. Inclusion of a spectrophotometer in the chromatography system provided for monitoring two parameters (“Sodium caprylate” and “Polymers and aggregates”) in a single test.
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About the authors
E. V. Khlybova
Kirov Science Research Institute of Hematology and Blood Transfusion, Russian Federal Medical-Biological Agency
Author for correspondence.
Email: niigpk@yandex.ru
Russian Federation, 72 Krasnoarmeyskaya Street, Kirov, 610027
E. S. Kormshchikova
Kirov Science Research Institute of Hematology and Blood Transfusion, Russian Federal Medical-Biological Agency
Email: niigpk@yandex.ru
Russian Federation, 72 Krasnoarmeyskaya Street, Kirov, 610027
A. V. Drobkova
Kirov Science Research Institute of Hematology and Blood Transfusion, Russian Federal Medical-Biological Agency
Email: niigpk@yandex.ru
Russian Federation, 72 Krasnoarmeyskaya Street, Kirov, 610027
I. V. Paramonov
Kirov Science Research Institute of Hematology and Blood Transfusion, Russian Federal Medical-Biological Agency
Email: niigpk@yandex.ru
Russian Federation, 72 Krasnoarmeyskaya Street, Kirov, 610027
