Synthesis and Structure of 7-Hydroxy-5-Oxo-2,3-Dihydro-5 H -[1,3]Thiazolo[3,2- a ]-Pyrimidine-6-Carboxylic Acid Ethyl Ester

I. V. Ukrainets; L. A. Grinevich; T. V. Alekseeva

doi:10.1007/s11094-017-1557-8

Synthesis and Structure of 7-Hydroxy-5-Oxo-2,3-Dihydro-5H-[1,3]Thiazolo[3,2-a]-Pyrimidine-6-Carboxylic Acid Ethyl Ester

Authors: Ukrainets I.V.¹, Grinevich L.A.¹, Alekseeva T.V.¹
Affiliations:
1. National Pharmaceutical University
Issue: Vol 51, No 1 (2017)
Pages: 56-59
Section: Drug Synthesis Methods and Manufacturing Technology
URL: https://journals.rcsi.science/0091-150X/article/view/244504
DOI: https://doi.org/10.1007/s11094-017-1557-8
ID: 244504

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Abstract

An effective method was developed for the preparation and x-ray diffraction analysis of the spatial structure of 7-hydroxy-5-oxo-2,3-dihydro-5H-[1, 3]thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester, which is of interest as a starting material for the synthesis of new, potentially biologically active derivatives of thiazolo[3,2-a]pyrimidine hydrogenated in the thiazole part of the molecule.