Synthesis and Pharmacological Potential of New 3-Mercapto-4-Amino(Pyrrolyl-1)-5-(Thienyl-2)-1,2,4-Triazole(4H) Derivatives
- Authors: Saidov N.B.1, Georgiyants V.A.2, Lipakova E.Y.3
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Affiliations:
- Tadzhik National University
- National Pharmaceutical University
- Kharkov Postgraduate Medical Academy
- Issue: Vol 51, No 1 (2017)
- Pages: 26-29
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244498
- DOI: https://doi.org/10.1007/s11094-017-1551-1
- ID: 244498
Cite item
Abstract
A synthesis of 4-amino-5-(2-thienyl)-1,2,4-triazol(4H)-3-ylthioacetanilides was developed, and these were chemically modified to produce 2-[5-(2′-thienyl-4-(1H-1-pyrrolyl)-4H-1,2,4-triazol-3-ylthio]acetanilidfes. The structures of the synthetic compounds were confirmed by 1H NMR spectroscopy. Predictions of pharmacological activity showed that the compounds synthesized here were likely to act on the CNS. The antitumor activity of the study compounds was assessed.
About the authors
N. B. Saidov
Tadzhik National University
Author for correspondence.
Email: narzullos@mail.ru
Tajikistan, Dushanbe
V. A. Georgiyants
National Pharmaceutical University
Email: narzullos@mail.ru
Ukraine, Kharkov
E. Yu. Lipakova
Kharkov Postgraduate Medical Academy
Email: narzullos@mail.ru
Ukraine, Kharkov