Synthesis, Antihelminthic and Insecticidal Activity of 2-[3-Methyl-6-Methoxy-7-(n-Propoxy)-3,4-Dihydroisoquinolin-1]Ethanoic Acid Amides
- Authors: Surikova O.V.1, Mikhailovskii A.G.1, Syropyatov B.Y.1, Yusov A.S.1, Khudyakova Y.D.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 51, No 1 (2017)
- Pages: 22-25
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244497
- DOI: https://doi.org/10.1007/s11094-017-1550-2
- ID: 244497
Cite item
Abstract
Cyclocondensation of O-n-propylated eugenol with cyanoacetamides was used to synthesize 2-[3-methyl-6-methoxy-7-(n-propoxy)-3,4-dihydroisoquinolin-1]ethanoic acid amides. The hydrochlorides of these compounds were tested for antihelminthic and insecticidal activity. The most active compounds were amides containing a cyclic amine fragment (pyrrolidine, piperidine, morpholine), which had greater activity than Pyrantel. Compounds without substituents at the amide nitrogen and the N-ethylamide had insecticidal activity at the levels of diazinon and pirimiphos.
About the authors
O. V. Surikova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm
A. G. Mikhailovskii
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm
B. Ya. Syropyatov
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm
A. S. Yusov
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm
Yu. D. Khudyakova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm