Synthesis and Antiviral Properties of Ethyl(3-ethyladamant-1-yl)carbamate
- Authors: Klimochkin Y.N.1, Moiseev I.K.1, Leonova M.V.1, Nikolaeva S.N.2, Boreko E.I.2
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Affiliations:
- Samara State Technical University
- Republican Scientific Applied Center for Epidemiology and Microbiology, Ministry of Health of the Republic of Belarus
- Issue: Vol 51, No 1 (2017)
- Pages: 13-17
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244495
- DOI: https://doi.org/10.1007/s11094-017-1548-9
- ID: 244495
Cite item
Abstract
The new adamantine derivative ethyl(3-ethyladamant-1-yl)carbamate was found to have high antiviral activity against herpes simplex virus and vaccinia viruses, as well as adenovirus (EC50 = 0.62, 5.15, and 48.5 μg/ml respectively). Activity against the herpesvirus was demonstrated in experiments in various cell cultures using different virus strains, including a variant resistant to acycloguanosine (ACG). Simultaneous application of ethyl(3-ethyladamant-1-yl)carbamate and ACG increased the inhibition of herpesvirus reproduction in cell cultures and decreased the mortality of laboratory animals with experimental herpesvirus neuroinfection as compared with the use of each substance alone. 3-Ethyladamant-1-yl)carbamate was a low-toxicity compound, did not inhibit DNAsynthesis in uninfected cell cultures, and its acute intragastric LD50 for white mice was 1831.8 mg/kg.
Keywords
About the authors
Yu. N. Klimochkin
Samara State Technical University
Author for correspondence.
Email: orgchem@samgtu.ru
Russian Federation, 244 Molodogvardeiskaya Street, Samara, 443100
I. K. Moiseev
Samara State Technical University
Email: orgchem@samgtu.ru
Russian Federation, 244 Molodogvardeiskaya Street, Samara, 443100
M. V. Leonova
Samara State Technical University
Email: orgchem@samgtu.ru
Russian Federation, 244 Molodogvardeiskaya Street, Samara, 443100
S. N. Nikolaeva
Republican Scientific Applied Center for Epidemiology and Microbiology, Ministry of Health of the Republic of Belarus
Email: orgchem@samgtu.ru
Belarus, 23 Filimonov Street, Minsk, 220114
E. I. Boreko
Republican Scientific Applied Center for Epidemiology and Microbiology, Ministry of Health of the Republic of Belarus
Email: orgchem@samgtu.ru
Belarus, 23 Filimonov Street, Minsk, 220114