Potential Synthetic Adaptogens. II. Synthesis and Pharmacological Activity of New Conformationally Labile Bromantane Analogs, N-[(Adamantan-1-YL)Methyl]-4-Bromoanilines
- Authors: Babushkin A.S.1, Navrotskii M.B.1, Novakov I.A.1, Orlinson B.S.1, Robinovich M.D.1, Sheikin D.S.1, Voloboev S.N.2
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Affiliations:
- Volgograd State Technical University
- Lukoil Volgograd Oil Refinery
- Issue: Vol 50, No 12 (2017)
- Pages: 781-787
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244478
- DOI: https://doi.org/10.1007/s11094-017-1531-5
- ID: 244478
Cite item
Abstract
New structural analogs of bromantane with greater conformational lability than the prototype were synthesized. Their physiological activity profiles were assessed in vivo. It was found that the analogs could be prepared under much milder conditions than bromantane and that their biological activity profiles dependedstrongly on the nature of adamantane substitution.
About the authors
A. S. Babushkin
Volgograd State Technical University
Email: chem@folium.ru
Russian Federation, 28 Prosp. im. Lenina, Volgograd, 400005
M. B. Navrotskii
Volgograd State Technical University
Email: chem@folium.ru
Russian Federation, 28 Prosp. im. Lenina, Volgograd, 400005
I. A. Novakov
Volgograd State Technical University
Email: chem@folium.ru
Russian Federation, 28 Prosp. im. Lenina, Volgograd, 400005
B. S. Orlinson
Volgograd State Technical University
Email: chem@folium.ru
Russian Federation, 28 Prosp. im. Lenina, Volgograd, 400005
M. D. Robinovich
Volgograd State Technical University
Email: chem@folium.ru
Russian Federation, 28 Prosp. im. Lenina, Volgograd, 400005
D. S. Sheikin
Volgograd State Technical University
Email: chem@folium.ru
Russian Federation, 28 Prosp. im. Lenina, Volgograd, 400005
S. N. Voloboev
Lukoil Volgograd Oil Refinery
Email: chem@folium.ru
Russian Federation, 55 Ul. 40-Let VLKSM, Volgograd, 400029