Email this article Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine
- Authors: Pichkhadze G.M.1, Smagulova G.S.1, Kadyrova D.M.1, Praliev K.D.2, Yu V.K.2
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Affiliations:
- S. D. Asfendiyarov Kazakh National Medical University
- A. B. Bekturov Institute of Chemical Sciences, Ministry of Education and Science of the Republic of Kazakhstan
- Issue: Vol 50, No 9 (2016)
- Pages: 600-602
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244445
- DOI: https://doi.org/10.1007/s11094-016-1498-7
- ID: 244445
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Abstract
Results from studies of the local anesthetic activity of LAS-54 [4-(benzoyloxy)-3-butoxypiperidinium chloride] (synthesized at the Laboratory of the Chemistry of Synthetic and Natural Drugs, Bekturov Institute of Chemical Sciences) in combination with epinephrine are presented. It was found that joint application of the vasoconstrictor with LAS-54, especially at low concentrations, prolonged infiltration, conduction, and spinal anesthesia.
About the authors
G. M. Pichkhadze
S. D. Asfendiyarov Kazakh National Medical University
Email: chem@folium.ru
Kazakhstan, Almaty
G. S. Smagulova
S. D. Asfendiyarov Kazakh National Medical University
Email: chem@folium.ru
Kazakhstan, Almaty
D. M. Kadyrova
S. D. Asfendiyarov Kazakh National Medical University
Email: chem@folium.ru
Kazakhstan, Almaty
K. D. Praliev
A. B. Bekturov Institute of Chemical Sciences, Ministry of Education and Science of the Republic of Kazakhstan
Email: chem@folium.ru
Kazakhstan, Almaty
V. K. Yu
A. B. Bekturov Institute of Chemical Sciences, Ministry of Education and Science of the Republic of Kazakhstan
Email: chem@folium.ru
Kazakhstan, Almaty
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