Vinpocetine Release From a Microencapsulated Form

Abstract

Microencapsulated vinpocetine was produced by liquid—liquid dispersion using a mixture of beeswax and cocoa oil in a 3:2 ratio as the carrier. The dispersion media were purified H₂O and sodium carboxymethylcellulose (Na-CMC) solution (2%). Drug release from the microcapsules was studied in vitro as a function of microcapsule size, shell material, and dispersion medium. The best characteristics were observed for microcapsules with a hydrophobic coating containing beeswax and cocoa oil in a 3:2 ratio of size 0.5 – 1 mm that were produced in Na-CMC solution (2%).