Synthesis and Antimicrobial, Analgesic, Antipyretic, and Immunotropic Activity of Methyl 3-Aryl-6-Amino-4-Aryl-5-Cyano-4H-Pyran-2-Carboxylates
- Authors: Mar’yasov M.A.1, Davydova V.V.1, Sheverdov V.P.1, Nasakin O.E.1, Gein V.L.2
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Affiliations:
- I. N. Ul’yanov Chuvash State University
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Issue: Vol 50, No 8 (2016)
- Pages: 519-522
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244427
- DOI: https://doi.org/10.1007/s11094-016-1480-4
- ID: 244427
Cite item
Abstract
A series of methyl 3-acyl-6-amino-4-aryl-5-cyano-4H-pyran-2-carboxylates were synthesized using the reaction of methyl 2,4-dioxobutanoates with arylidenemalononitriles in EtOAc in the presence of catalytic amounts of morpholine or piperidine. The structures of the compounds were elucidated using IR, PMR, 13C NMR, and mass spectral data. The antimicrobial, analgesic, and antipyretic activities of the synthesized compounds and their influence on antibody response were studied.
About the authors
M. A. Mar’yasov
I. N. Ul’yanov Chuvash State University
Author for correspondence.
Email: marsikprovisor@mail.ru
Russian Federation, Cheboksary, 428010
V. V. Davydova
I. N. Ul’yanov Chuvash State University
Email: geinvl48@mail.ru
Russian Federation, Cheboksary, 428010
V. P. Sheverdov
I. N. Ul’yanov Chuvash State University
Email: geinvl48@mail.ru
Russian Federation, Cheboksary, 428010
O. E. Nasakin
I. N. Ul’yanov Chuvash State University
Email: geinvl48@mail.ru
Russian Federation, Cheboksary, 428010
V. L. Gein
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, Perm, 614990