Kinetics of Ibuprofen Release From Magnetic Nanoparticles Coated with Chitosan, Peg and Dextran

Abstract

In this study, iron oxide magnetic nanoparticles (MNPs) were synthesized and their surfaces were functionalized with various polymers. Then, ibuprofen was attached and the kinetics of drug release from this system at various temperatures and pH was studied. The nanoparticles were synthesized by the Massart co-precipitation method. Their surfaces were functionalized with chitosan, PEG or dextran. The concentration of released ibuprofen was measurement in vitro by spectrofluorometric methods. The mechanism of drug release from the carriers was analyzed in the Korsmeyer – Peppas model. According to the results, the amount of ibuprofen released depends on the type of material by which MNPs are coated. Nanoparticles coated with dextran seem to be the most promising material for ibuprofen release. In the Korsmeyer – Peppas model, the values of diffusion exponent n characterize the mechanism of drug release. The values obtained for dextran and PEG point to the Fickian diffusion, while the diffusion mechanism for chitosan is anomalous. These results show the possibility of practical use of the material synthesized in living organisms.