Effects of Isoflavonoids from Maackia Amurensis Roots on the Metabolic Reactions of the Liver in Experimental Toxic Hepatitis
- Authors: Kulesh N.I.1, Fedoreev S.A.1, Veselova M.V.1, Kushnerova N.F.2, Fomenko S.E.2, Sprygin V.G.2, Momot T.V.3
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Affiliations:
- G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences
- V. I. Il’ich Pacific Ocean Institute, Far Eastern Branch, Russian Academy of Sciences
- Far Eastern Federal University
- Issue: Vol 50, No 7 (2016)
- Pages: 451-457
- Section: Medicinal Plants
- URL: https://journals.rcsi.science/0091-150X/article/view/244415
- DOI: https://doi.org/10.1007/s11094-016-1468-0
- ID: 244415
Cite item
Abstract
A complex of isoflavonoids containing more than 78% isoflavone and pterocarpan glycosides was obtained from an alcoholic extract of the roots of the Amur maackia, a far eastern relict tree (Maackia amurensis Ruper et Maxim.). This complex contained the 7-O-gentiobiosides of daidzein, genistein, afromosin, pseudobaptigenin, formononetin, and 5-O-methylgenistein, the 3-O-gentiobiosides of maackiain and medicarpin, the compounds daidzin, and genistein, 7-O-primverosylformononetin, and the novel 7-O-primverosylpseudobaptigenin. Studies using a model of toxic hepatitis induced by poisoning of rats with carbon tetrachloride addressed the effects of the complex of isoflavonoids on the state of carbohydrate metabolism in the rat liver. Administration of this complex to animals with CCl4 hepatitis decreased the activity of marker enzymes for cytolysis and the specific weight of the liver, promoted maintenance of the blood glucose and oxidized nicotinamide coenzyme (NAD+) levels, and normalized pyruvate and lactate levels in the animals’ livers. The isoflavonoid complex extracted from Maackia amurensis was more effective in restoring the reactions of liver carbohydrate metabolism (gluconeogenesis, Krebs cycle) than the reference hepatoprotector Legalon®.
Keywords
About the authors
N. I. Kulesh
G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences
Email: fedoreev-s@mail.ru
Russian Federation, 159 100 Years of Vladivostok Prospekt, Vladivostok, 690022
S. A. Fedoreev
G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences
Author for correspondence.
Email: fedoreev-s@mail.ru
Russian Federation, 159 100 Years of Vladivostok Prospekt, Vladivostok, 690022
M. V. Veselova
G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences
Email: fedoreev-s@mail.ru
Russian Federation, 159 100 Years of Vladivostok Prospekt, Vladivostok, 690022
N. F. Kushnerova
V. I. Il’ich Pacific Ocean Institute, Far Eastern Branch, Russian Academy of Sciences
Email: fedoreev-s@mail.ru
Russian Federation, 43 Baltiiskaya Street, Vladivostok, 690041
S. E. Fomenko
V. I. Il’ich Pacific Ocean Institute, Far Eastern Branch, Russian Academy of Sciences
Email: fedoreev-s@mail.ru
Russian Federation, 43 Baltiiskaya Street, Vladivostok, 690041
V. G. Sprygin
V. I. Il’ich Pacific Ocean Institute, Far Eastern Branch, Russian Academy of Sciences
Email: fedoreev-s@mail.ru
Russian Federation, 43 Baltiiskaya Street, Vladivostok, 690041
T. V. Momot
Far Eastern Federal University
Email: fedoreev-s@mail.ru
Russian Federation, 8 Sukhanov Street, Vladivostok, 690950