Synthesis and Pharmacological Properties of 1,3-Bis[(S)Phenylethyl]Imidazolidine-2-Thione
- Authors: Umar M.N.1, Shoaib M.2, Sadiq M.1, Ayaz M.1, Miskeen S.1, Shah I.2, Khan I.3, Rahid H.U.4, Ilahi I.5, Khan S.W.6
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Affiliations:
- Department of Chemistry, University of Malakand
- Department of Pharmacy, University of Malakand
- Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University
- Department of Chemistry, Sarhad University of Science and Information Technology
- Department of Zoology, University of Malakand
- Department of Chemistry, SBBU Sheringal
- Issue: Vol 50, No 6 (2016)
- Pages: 382-387
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244400
- DOI: https://doi.org/10.1007/s11094-016-1456-4
- ID: 244400
Cite item
Abstract
Enantiomerically and diastereomerically pure thiourea derivative (compound I) has been synthesized in two steps starting from (S)-1-phenylethanamine and 1,2-dibromoethane. Compound I was screened for various biochemical parameters including blood glucose level, serum total cholesterol level, serum bilirubin and triglyceride levels, serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) activity in New Zealand White (NZW) rabbits. Compound I was also screened for brine shrimp cytotoxicity, antileishmanial and antioxidant activity. Acute toxicity tests in NZW rabbits were performed and the results showed that compound I was safe up to 2 mg/mL/kg rabbit body weight. For the blood parameters, it was found that compound I caused slightly reduced blood glucose level, increased blood serum bilirubin, ALP and SGPT levels, and caused no changes in cholesterol and triglyceride levels. Thus, results show that compound I possesses good cytotoxic, poor antileishmanial activity, and no prominent antioxidant activity.
About the authors
Muhammad Naveed Umar
Department of Chemistry, University of Malakand
Email: mohammadshoaib13@yahoo.com
Pakistan, Chakdara, Dir Lower, KPK
Mohammad Shoaib
Department of Pharmacy, University of Malakand
Author for correspondence.
Email: mohammadshoaib13@yahoo.com
Pakistan, Chakdara, Dir Lower, KPK
Mohammad Sadiq
Department of Chemistry, University of Malakand
Email: mohammadshoaib13@yahoo.com
Pakistan, Chakdara, Dir Lower, KPK
Muhammad Ayaz
Department of Chemistry, University of Malakand
Email: mohammadshoaib13@yahoo.com
Pakistan, Chakdara, Dir Lower, KPK
Sumaira Miskeen
Department of Chemistry, University of Malakand
Email: mohammadshoaib13@yahoo.com
Pakistan, Chakdara, Dir Lower, KPK
Ismail Shah
Department of Pharmacy, University of Malakand
Email: mohammadshoaib13@yahoo.com
Pakistan, Chakdara, Dir Lower, KPK
Imran Khan
Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University
Email: mohammadshoaib13@yahoo.com
Pakistan, Islamabad
Haroon Ur Rahid
Department of Chemistry, Sarhad University of Science and Information Technology
Email: mohammadshoaib13@yahoo.com
Pakistan, Peshawar, KPK
Ikram Ilahi
Department of Zoology, University of Malakand
Email: mohammadshoaib13@yahoo.com
Pakistan, Chakdara, Dir Lower, KPK
Sher Wali Khan
Department of Chemistry, SBBU Sheringal
Email: mohammadshoaib13@yahoo.com
Pakistan, Sheringal, KPK