Mechanisms of Antiradical Activity of 2,3,5,6,8-Pentahydroxy-7-Ethyl-1,4-Naphthoquinone (A Review)

O. S. Talalaeva; Ya. F. Zverev; V. M. Bryukhanov

doi:10.1007/s11094-016-1450-x

Mechanisms of Antiradical Activity of 2,3,5,6,8-Pentahydroxy-7-Ethyl-1,4-Naphthoquinone (A Review)

Authors: Talalaeva O.S.¹, Zverev Y.F.¹, Bryukhanov V.M.¹
Affiliations:
1. Altai State Medical University, Ministry of Health of the Russian Federation
Issue: Vol 50, No 6 (2016)
Pages: 353-357
Section: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
URL: https://journals.rcsi.science/0091-150X/article/view/244393
DOI: https://doi.org/10.1007/s11094-016-1450-x
ID: 244393

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Abstract

The role of the antioxidant properties of 2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone in the manifestation of its pharmacological effects is reviewed. Issues with pleiotropic cellular-molecular mechanisms of echinochrome A action are considered with emphasis on the unique antioxidant activity of 2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone. These properties in combination with a low destructive potential account for the prospects of expanding the therapeutic use of echinochrome A.