Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
- Authors: Sajid Z.1, Ahmad M.1, Aslam S.2, Ashfaq U.A.3, Zahoor A.F.1, Saddique F.A.1, Parvez M.4, Hameed A.5, Sultan S.6, Zgou H.7, Hadda T.B.8
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Affiliations:
- Department of Chemistry, Government College University
- Department of Chemistry, Government College Women University
- Department of Bioinformatics and Biotechnology, Government College University
- Department of Chemistry, University of Calgary
- HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi
- Faculty of Pharmacy, Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA
- Ibn Zohr University, Polydisciplinary Faculty
- Laboratoire Chimie Matériaux, FSO, Université Mohammed Premier
- Issue: Vol 50, No 3 (2016)
- Pages: 172-180
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244338
- DOI: https://doi.org/10.1007/s11094-016-1417-y
- ID: 244338
Cite item
Abstract
Novel structural hybrids of pyrazolobenzothiazine and triazole ring systems have been prepared to observe a synergistic effect of the two ring systems. The methodology involves condensation of pyrazolobenzothiazine rings with methyl chloroacetate, followed by hydrazide formation. The hydrazides were converted to triazoles through the formation of intermediate potassium salts of dithiocarbazate. The final compounds as well as intermediates were screened for their antibacterial activity against a multidrug resistant strain of Staphylococcus aureus. It was interesting to observe that dithiocarbazates (7a, 7b) and target triazoles (8a, 8b) exhibited antibacterial activity.
About the authors
Zara Sajid
Department of Chemistry, Government College University
Email: matloob_123@yahoo.com
Pakistan, Faisalabad, 38000
Matloob Ahmad
Department of Chemistry, Government College University
Author for correspondence.
Email: matloob_123@yahoo.com
Pakistan, Faisalabad, 38000
Sana Aslam
Department of Chemistry, Government College Women University
Email: matloob_123@yahoo.com
Pakistan, Faisalabad, 38000
Usman Ali Ashfaq
Department of Bioinformatics and Biotechnology, Government College University
Email: matloob_123@yahoo.com
Pakistan, Faisalabad, 38000
Ameer Fawad Zahoor
Department of Chemistry, Government College University
Email: matloob_123@yahoo.com
Pakistan, Faisalabad, 38000
Furqan Ahmad Saddique
Department of Chemistry, Government College University
Email: matloob_123@yahoo.com
Pakistan, Faisalabad, 38000
Masood Parvez
Department of Chemistry, University of Calgary
Email: matloob_123@yahoo.com
Canada, 2500 University Drive, N. W. Calgary, Alberta, T2N 1N4
Abdul Hameed
HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi
Email: matloob_123@yahoo.com
Pakistan, Karachi
Sadia Sultan
Faculty of Pharmacy, Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA
Email: matloob_123@yahoo.com
Malaysia, Puncak Alam Campus, Bandar Puncak Alam, Selangor Darul Ehsan, 42300
Hsaine Zgou
Ibn Zohr University, Polydisciplinary Faculty
Email: matloob_123@yahoo.com
Morocco, Ouarzazate
Taibi Ben Hadda
Laboratoire Chimie Matériaux, FSO, Université Mohammed Premier
Email: matloob_123@yahoo.com
Morocco, Oujda, 60000