Synthesis and Antiviral Activity of Hydroxy-Substituted Benzaldehydes and Related Compounds

O. I. Shadyro; V. L. Sorokin; G. A. Ksendzova; O. V. Savinova; S. N. Samovich; N. I. Pavlova; G. I. Polozov; E. I. Boreko

doi:10.1007/s11094-016-1414-1

Synthesis and Antiviral Activity of Hydroxy-Substituted Benzaldehydes and Related Compounds

Autores: Shadyro O.I.¹, Sorokin V.L.¹, Ksendzova G.A.¹, Savinova O.V.¹, Samovich S.N.², Pavlova N.I.¹, Polozov G.I.¹, Boreko E.I.²
Afiliações:
1. Belarusian State University
2. State Research and Practical Center for Epidemiology and Microbiology
Edição: Volume 50, Nº 3 (2016)
Páginas: 156-158
Seção: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244335
DOI: https://doi.org/10.1007/s11094-016-1414-1
ID: 244335

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A series of hydroxy-substituted benzaldehydes and related compounds were synthesized and studied in cell culture against herpes simplex type I (HSV-1) and influenza A (H7N1) viruses. It was found that salicylaldehyde, 2,3-dihydroxybenzaldehyde, and gossypol could suppress HSV-1 replication. The structure–activity relationship of the series of hydroxylated benzaldehydes was analyzed.