Synthesis and Antiviral Activity of Hydroxy-Substituted Benzaldehydes and Related Compounds
- Authors: Shadyro O.I.1, Sorokin V.L.1, Ksendzova G.A.1, Savinova O.V.1, Samovich S.N.2, Pavlova N.I.1, Polozov G.I.1, Boreko E.I.2
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Affiliations:
- Belarusian State University
- State Research and Practical Center for Epidemiology and Microbiology
- Issue: Vol 50, No 3 (2016)
- Pages: 156-158
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244335
- DOI: https://doi.org/10.1007/s11094-016-1414-1
- ID: 244335
Cite item
Abstract
A series of hydroxy-substituted benzaldehydes and related compounds were synthesized and studied in cell culture against herpes simplex type I (HSV-1) and influenza A (H7N1) viruses. It was found that salicylaldehyde, 2,3-dihydroxybenzaldehyde, and gossypol could suppress HSV-1 replication. The structure–activity relationship of the series of hydroxylated benzaldehydes was analyzed.
Keywords
About the authors
O. I. Shadyro
Belarusian State University
Email: chem@folium.ru
Belarus, Minsk
V. L. Sorokin
Belarusian State University
Email: chem@folium.ru
Belarus, Minsk
G. A. Ksendzova
Belarusian State University
Email: chem@folium.ru
Belarus, Minsk
O. V. Savinova
Belarusian State University
Email: chem@folium.ru
Belarus, Minsk
S. N. Samovich
State Research and Practical Center for Epidemiology and Microbiology
Email: chem@folium.ru
Belarus, Minsk
N. I. Pavlova
Belarusian State University
Email: chem@folium.ru
Belarus, Minsk
G. I. Polozov
Belarusian State University
Email: chem@folium.ru
Belarus, Minsk
E. I. Boreko
State Research and Practical Center for Epidemiology and Microbiology
Email: chem@folium.ru
Belarus, Minsk