Experimental Study of the Biocompatibility of Soft Tissues and a Finely Dispersed Sorbent Containing Silver
- Authors: Popova T.V.1, Tolstikova T.G.2, Letyagin A.Y.1, Rachkovskaya L.N.1, Burmistrov V.A.1
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Affiliations:
- Institute of Clinical and Experimental Lymphology
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 50, No 3 (2016)
- Pages: 152-155
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244334
- DOI: https://doi.org/10.1007/s11094-016-1413-2
- ID: 244334
Cite item
Abstract
The physicochemical and biological properties of a new finely dispersed Si- and Al-containing sorbent are presented. Its modification using silver nanoclusters immobilized on the sorbent-particle surface is described. The parameters of the sorbent porous structure, its sorption activity, and the rate of silver release from the sorbent surface in contact with a liquid medium are determined. Both the sorbent matrix and the original silver-modified sorbent are well tolerated by experimental animals upon intramuscular administration and cause no changes in the behavior, weight, and appearance of the animals. Results from studies of the leukocyte, platelet, and red-blood-cell pools of peripheral blood also confirm that the sorbents are biocompatible with body tissues.
About the authors
T. V. Popova
Institute of Clinical and Experimental Lymphology
Author for correspondence.
Email: argentum.popova@mail.ru
Russian Federation, Novosibirsk, 630117
T. G. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Author for correspondence.
Email: tg_tolstikova@mail.ru
Russian Federation, Novosibirsk, 630090
A. Yu. Letyagin
Institute of Clinical and Experimental Lymphology
Email: tg_tolstikova@mail.ru
Russian Federation, Novosibirsk, 630117
L. N. Rachkovskaya
Institute of Clinical and Experimental Lymphology
Email: tg_tolstikova@mail.ru
Russian Federation, Novosibirsk, 630117
V. A. Burmistrov
Institute of Clinical and Experimental Lymphology
Email: tg_tolstikova@mail.ru
Russian Federation, Novosibirsk, 630117