Improving Pharmaceutical Characteristics of Curcumin by Alginate/Pectin Microparticles
- Authors: Sattarahmady N.1,2, Moosavi-Movahedi A.A.3, Bazzi P.3, Heli H.4,2, Pourtakdoust S.3
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Affiliations:
- Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences
- Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences
- Institute of Biochemistry and Biophysics, University of Tehran
- Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences
- Issue: Vol 50, No 3 (2016)
- Pages: 131-136
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244331
- DOI: https://doi.org/10.1007/s11094-016-1410-5
- ID: 244331
Cite item
Abstract
This study was aimed at the preparation of curcumin-loaded alginate/pectin microparticles (beads) in order to enhance the pharmaceutical effect of curcumin as a drug for colon related diseases. For this purpose, three types of curcumin-loaded beads were prepared with different alginate/pectin ratios (100/0, 75/25 and 50/50) and studied in various experiments including the release of curcumin from beads and swelling of beads in buffer solutions of simulated gastric, intestinal, and colon fluids. The results of curcumin releasing experiments under conditions mimicking stomach to colon transit showed that the beads with higher content of pectin exhibit stronger curcumin entrapment, slower release rate, and lower swelling. Thus, 50/50 alginate/pectin composition has minimum release in the upper parts of gastrointestinal tract (stomach and intestine). However, when these beads reached colonic buffer medium, the curcumin release suddenly increased. Therefore, beads with 50/50 alginate/pectin compositions could be useful as a suitable carrier for curcumin delivery to colon. Moreover, the stability and chemical protection of curcumin encapsulated in these beads was confirmed by high performance liquid chromatography measurements after a period of six months.
Keywords
About the authors
N. Sattarahmady
Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences
Author for correspondence.
Email: nsattar@sums.ac.ir
Iran, Islamic Republic of, Shiraz; Shiraz
A. A. Moosavi-Movahedi
Institute of Biochemistry and Biophysics, University of Tehran
Email: nsattar@sums.ac.ir
Iran, Islamic Republic of, Tehran
P. Bazzi
Institute of Biochemistry and Biophysics, University of Tehran
Email: nsattar@sums.ac.ir
Iran, Islamic Republic of, Tehran
H. Heli
Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences
Email: nsattar@sums.ac.ir
Iran, Islamic Republic of, Shiraz; Shiraz
S. Pourtakdoust
Institute of Biochemistry and Biophysics, University of Tehran
Email: nsattar@sums.ac.ir
Iran, Islamic Republic of, Tehran