Influence of Melatonin-Correcting Drugs (Melaxen and Valdoxan) on the Levels of Superoxide Dismutase and Catalase Gene Transcription in Rats with Experimental Hyperthyroidism

T. N. Popova; A. A. Agarkov; M. V. Gorbenko; S. S. Popov; K. K. Shul’gin

doi:10.1007/s11094-016-1409-y

Influence of Melatonin-Correcting Drugs (Melaxen and Valdoxan) on the Levels of Superoxide Dismutase and Catalase Gene Transcription in Rats with Experimental Hyperthyroidism

Authors: Popova T.N.¹, Agarkov A.A.¹, Gorbenko M.V.¹, Popov S.S.², Shul’gin K.K.¹
Affiliations:
1. Voronezh State University
2. N. N. Burdenko Voronezh State Medical Academy
Issue: Vol 50, No 3 (2016)
Pages: 127-130
Section: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
URL: https://journals.rcsi.science/0091-150X/article/view/244330
DOI: https://doi.org/10.1007/s11094-016-1409-y
ID: 244330

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Abstract

The influence of the melatonin-correcting drugs melaxen and Valdoxan on the gene-transcription level of superoxide dismutase (SOD, EC 1.15.1.1) and catalase (EC 1.11.1.6) in liver and heart of rats with hyperthyroidism has been investigated. Administration of these drugs to rats with model pathology leads to changes in SOD and catalase expression in their tissues toward the control values.