Near-Infrared Spectroscopy for the Analysis of Solid Dosage Forms: Does the Shell Influence Drug Identification Results?
- Authors: Gurzhieva A.G.1, Elizarova T.E.2, Morozova M.A.1
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Affiliations:
- Department of Pharmaceutical and Toxicological Chemistry, Peoples’ Friendship University of Russia
- Farmanaliz Company
- Issue: Vol 50, No 2 (2016)
- Pages: 114-119
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244328
- DOI: https://doi.org/10.1007/s11094-016-1407-0
- ID: 244328
Cite item
Abstract
Several practical issues related to the need for sample preparation of solid dosage forms for their identification by near-infrared (NIR) spectroscopy are discussed. It is shown using a classification method, i.e., discriminant analysis, that the tablet coating regardless of its thickness did not affect the accuracy of the analytical results. However, calibration error due to the influence of opaque hard gelatin shells is possible during identification using diffuse reflectance spectra. It is proven that errors in assigning a sample to one group or another are avoided and; therefore, it is rapidly identified if the hard gelatin shell is removed and NIR spectra are recorded directly from the capsule contents.
Keywords
About the authors
A. G. Gurzhieva
Department of Pharmaceutical and Toxicological Chemistry, Peoples’ Friendship University of Russia
Author for correspondence.
Email: anytkagu18@gmail.com
Russian Federation, 8 – 2 Miklukho-Maklaya St., Moscow, 117198
T. E. Elizarova
Farmanaliz Company
Email: anytkagu18@gmail.com
Russian Federation, 2 Chermyanskaya St., Moscow, 127282
M. A. Morozova
Department of Pharmaceutical and Toxicological Chemistry, Peoples’ Friendship University of Russia
Email: anytkagu18@gmail.com
Russian Federation, 8 – 2 Miklukho-Maklaya St., Moscow, 117198