Preparation and Molecular Composition of an Inclusion Complex of Dilsulfiram and Hydroxypropyl-β-Cyclodextrin

Abstract

An original method is proposed for preparing an inclusion complex based on disulfiram with hydroxypropyl-β-cyclodextrin for the treatment of cataract. Preparation of soluble product required a molar ratio of hydroxypropyl-β-cyclodextrin to disulfiram of at least 2:1, while the molar ratio of components in the inclusion complex was 1:1. Gel permeation chromatography was used to measure the mean hydrodynamic diameter of hydroxypropyl-β-cyclodextrin and inclusion complex molecules, and their molecular weights were calculated – which in both cases were 1.0 kDa. A scheme for the equilibrium of the inclusion complex is proposed.